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Computational haemodynamics

Model of Blood Circulation

The model is based on the set of differential equations: mass and momentum balance laws, state equation. The vessels are connected with each other at the nodes and with the heart inlets/outlets through the boundary conditions set that is formed by Poiseuille's pressure drop conditions, mass balance equation combined with the appropriate compatibility condition. The model allows us to calculate cross section of every vessel, pressure and velocity of blood everywhere in the cardiovascular system in any moment of time. We can take into consideration hemorrhages, effects of different forces, the spread of drugs. To study influence of implants or pathologies on the blood flow we use more mathematical models.

Fiber model of the elastic vessel wall

The wall is represented by the set of fibers. We imitate the response of the elastic surface to a deformation as the response of fiber collection to the same deformation.

By such representation we can simulate elastic properties of healthy vessels and vessels with implants (for example cava-filter).

Simulation model of atherosclerotic plaque

Three-layer structure in the model corresponds to anatomy of real plaque. The wall and fibrous cap are represented by the set of fibers, lipid pool is represented by the set of springs. The model allows us to reproduce elastic properties of atherosclerotic vessel wall.

3D modelling of blood flow

This method is based on the system of Navier-Stokes equations and allows us to describe blood flow in details in the domain of interest (for example near the cava-filter with thrombus).

The example of the adaptive mesh for the flow over a model cava filter problem.

Modelling of blood flow in networks of vessels with pathologies

Atherosclerosis and placed implants such as cava-filters and stents can be taken into consideration by the model of blood circulation in two ways:
1)through the state equation. This pressure dependence of cross section can be modified by means of fiber model of the elastic vessel wall or by the model of atherosclerotic plaque.
2)we describe blood flow in 3D domain of interest and couple it with the 1D model of global blood circulation.

Friendly graphical interface for models

Touchpad for work with models and for visualization of results.


search?q=playground%3Ablood-pressure.mp4%20360%2C240%20autoBuffering&btnI=lucky search?q=playground%3Ablood-velocity.mp4%20360%2C240%20autoBuffering&btnI=lucky

Team members:

Vassilevski Yuri (INM RAS), Simakov Sergey (MIPT), Salamatova Victoria (SEC INM RAS), Ivanov Yuri (INM RAS), Dobroserdova Tatiana (MSU), Kramarenko Vasiliy (MIPT), Gamilov Timur (MIPT)

Working group on mathematical models and numerical methods in biomathematics

Ph.D. thesis

Dobroserdova T. Mathematical Modelling of Blood Flow in the vessel network with pathologies or implants. (in Russian)

Publications on haemodynamics:

T. Gamilov, Yu. Ivanov, P. Kopylov, S. Simakov, Yu. Vassilevski. Patient specific haemodynamic modeling after occlusion treatment in leg. Mathematical Modelling of Natural Phenomena. 9(6), 85--97 (2014)

S. Simakov, T. Gamilov, Y.N. Soe. Computational study of blood flow in lower extremities under intense physical load. Russian Journal of Numerical Analysis and Mathematical Modelling. 28(5), 485--504 (2013)

T. Dobroserdova, M. Olshanskii. A finite element solver and energy stable coupling for 3D and 1D fluid models. Computer Methods in Applied Mechanics and Engineering. Volume 259, pp. 166 -- 176 (2013)

Yu. Vassilevskii, S. Simakov, V. Salamatova, Yu. Ivanov, T. Dobroserdova. Numerical issues of modelling blood flow in networks of vessels with pathologies. Russian Journal of Numerical Analysis and Mathematical Modelling, Vol. 26, No. 6, 2011, pp. 605-622

Y. Vassilevski, S. Simakov, V. Salamatova, Y. Ivanov, T. Dobroserdova. Vessel wall models for simulation of atherosclerotic vascular networks. Mathematical Modelling of Natural Phenomena, Vol. 6, No. 7, 2011, pp. 82-99

Y. Vassilevski, S. Simakov, V. Salamatova, Y. Ivanov, T. Dobroserdova. Blood flow simulation in atherosclerotic vascular network using fiber-spring representation of diseased wall. Mathematical Modelling of Natural Phenomena, Vol. 6, No. 5, 2011, pp. 333-349

Y.V. Vassilevski, S.S. Simakov, S.A. Kapranov. A multi-model approach to intravenous filter optimization. International Journal for Numerical Methods in Biomedical Engineering, V.26, pp.915-925, 2010

Y.A. Ivanov, T.K. Dobroserdova. Mathematical modelling of intravenous filter influnce on the blood system haemodymaics. Scientific and Technical Bulletin of St. Petersburg State University of IT, Mechanics and Optics, V.04(68), pp.94-98, 2010

haemodynamics.1412315961.txt.gz · Last modified: 2014/10/03 09:59 by Sergey Simakov